Attuale ruolo: Prof. Associato
SSD: BIO12
Edificio: PTV, settore D
piano: 1°
studio: stanza 118
telefono: 06-2090-0672
mail: fabrizio.barbetti@uniroma2.it
Biographical
Birth place: Rome, Italy; birth date June/29/1952
Education
1977: M.D. University La Sapienza, Rome, Italy
1981: Specialty Board in Endocrinology. University La Sapienza, Rome
1988: Ph.D. University La Sapienza, Rome, Italy
Post-graduate educ.
1987-1990: Fogarty Fellow, Diabetes Branch, NIDDK, National Institutes of Health, Bethesda,
MD, USA
1990-1991:Visiting Associate, Diabetes Branch, NIDDK, National Institutes of Health,
Bethesda, MD, USA
Positions held
1992-1994: Scientific Consultant, H. S. Raffaele, Rome, and DI.BI.T, Milan, Italy.
1995-2000: Chief, Laboratory of Molecular Pathology of Diabetes, DIBIT, H. S. Raffaele, Milan,
and Clinical Staff Coordinator, Diabetes and Endocrine Clinic; H. S. Raffaele, Rome, Italy.
2000-2009: Chief, Laboratory of Molecular Endocrinology and Metabolism, Biomedical
Park Foundation S Raffaele, Rome, Italy
2000-present: Senior Investigator, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
Academic positions
2005-present: Associate Professor of Clinical Biochemistry and Molecular Biology, Department of Experimental Medicine and Surgery, University Tor Vergata, Rome, Italy
Aug/2009-Jan/2010: Visiting Associate Professor at Division of Endocrinology, Diabetes
and Endocrinology Research Center (DERC), Columbia University, Naomi Berrie Diabetes Center
New York, NY
Teaching
Prof. F. Barbetti teaches Clinical Biochemisty and Clinical Molecular Biology classes at University of Tor Vergata for students of Medicine and Surgery (course in Italian), for students of Medicine and Surgery (course in English) and for students of Medical Biotechnologies (course in Italian)
Research
Prof. F. Barbetti focuses his scientific interests on molecular genetics, genotype-phenotype correlations, mechanisms of disease and gene discovery of monogenic forms of diabetes mellitus, of hyperinsulinism and hypoglycemia, and of severe insulin resistance
Cenni biografici. Nato a Roma il 29/6/1952.
Formazione
1977: Laurea in Medicina e Chirurgia, Univ. La Sapienza, Roma
1981: Specializzazione in Endocrinologia, Univ. La Sapienza, Roma
1988: Dottorato di Ricerca in Scienze Endocrinologiche e Metaboliche, Univ. La Sapienza, Roma 1987-1990: Fogarty fellow, Diabetes Branch, NIDDK, NIH, Bethesda, MD, USA;
1990-1991: Visiting Associate, Diabetes Branch, NIDDK, NIH, Bethesda, MD, USA
Posizioni accademiche
2005-presente: Prof. Associato Biochimica Clinica e Biologia Molecolare Clinica, Università Tor Vergata, Roma.
Agosto 2009-Gennaio 2010: Visiting Associate Professor, Dipartimento di Medicina, Sezione Endocrinologia, Diabetes and Endocrinology Research Center (DERC), Columbia University, Naomi Berrie Diabetes Center, New York, NY, USA
Attività didattica
La attività didattica del Prof. Barbetti si esplica presso l’Università Tor Vergata nei corsi di laurea di Medicina e Chirurgia in italiano, di Medicina e Chirurgia in inglese e di Biotecnologie Mediche
Attività scientifica
Gli interessi scientifici del Prof. Barbetti si concentrano sullo studio genotipo-fenotipo, dei meccanismi di malattia e delle scoperta di nuovi geni alla base delle forme monogeniche di diabete mellito, di iperinsulinismo/ipoglicemia e di insulino-resistenza estrema.
Pubblicazioni selezionate
Russo L, Iafusco D, Brescianini S, Nocerino V, Bizzarri C, Toni S, Cerutti F, Monciotti C, Pesavento R, Iughetti L, Bernardini L, Bonfanti R, Gargantini L, Vanelli M, Aguilar-Bryan L, Stazi A, Grasso V, Colombo C, Barbetti F. (2011) Permanent diabetes during the first year of life: multiple gene screening in 54 patients. Diabetologia 54:1693-1701
Iafusco D, Bizzarri C, Cadario F, Pesavento R, Tonini G, Tumini S, Cauvin V, Colombo C, Bonfanti R, Barbetti F. (2011) No beta cell desensitisation after a median of 68 months on glibenclamide therapy in patients with KCNJ11-associated permanent neonatal diabetes. Diabetologia 54:2736-2738
Iafusco D, Massa O, Pasquino B, Colombo C, Iughetti L, Bizzarri C, Mammì C, Lo Presti D, Suprani T, Schiaffini R, Nichols CG, Russo L, Grasso V, Meschi F, Bonfanti R, Brescianini S, Barbetti F (2012). Minimal Incidence of Neonatal/Infancy Onset Diabetes in Italy is 1:90,000 live births. Acta Diabetol 49:405-408
Maiorana A, Barbetti F, Boiani A, Rufini V, Pizzoferro M, Francalanci P, Faletra F, Colin G Nichols, Grimaldi C, de Ville de Goyet J, Rahier J, Henquin J-C, Dionisi-Vici C. (2014) Focal congenital hyperinsulinism managed by medical treatment: a diagnostic algorithm based on molecular genetic screening. Clin Endocrinol, 81:679-688
Iafusco D, Salardi S, Chiari G, Toni S, Rabbone I, Pesavento R, Pasquino B, de Benedictis A, Maltoni G, Colombo C, Russo L, Massa O, Sudano M, Cadario F, Porta M, Barbetti F. (2014) No sign of proliferatve retinopathy in 15 patients with Permanent Neonatal Diabetes Mellitus with a median diabetes duration of 24 years. Diabetes Care 37:e181-e182
Delvecchio M, Ludovico O, Menzaghi C, Di Paola R, Zelante L, Marucci A, Grasso V, Trischitta V, Carella M, Barbetti F. (2014) Low prevalence of HNF1A mutations after molecular screening of multiple MODY genes in 58 Italian families recruited in the pediatric or adult diabetes clinic from a single Italian hospital. Diabetes Care 37:e258-e260
Liu M, Sun J, Cui J, Chen W, Guo H, Barbetti F, Arvan P. (2015) INS-gene mutations: from genetics and beta cell biology and clinical disease. Mol Aspects Med, published online 24 Dicembre 2014