Dipartimento di Medicina Sperimentale e Chirurgia

Barbetti Fabrizio

1

Attuale ruolo: Prof. Associato

SSD:  BIO12

Edificio:   PTV, settore D

piano: 1°

studio:  stanza 118

telefono: 06-2090-0672

mail: fabrizio.barbetti@uniroma2.it

 

Biographical

Birth place: Rome, Italy;  birth date June/29/1952

 

Education

1977: M.D. University La Sapienza, Rome, Italy

1981: Specialty Board in Endocrinology. University La Sapienza, Rome

1988: Ph.D. University La Sapienza, Rome, Italy

 

Post-graduate educ.

1987-1990: Fogarty Fellow, Diabetes Branch, NIDDK, National Institutes of Health, Bethesda,

MD, USA

1990-1991:Visiting Associate, Diabetes Branch, NIDDK, National Institutes of Health,

Bethesda, MD, USA

 

Positions held

1992-1994: Scientific Consultant, H. S. Raffaele, Rome, and DI.BI.T, Milan, Italy.

1995-2000: Chief, Laboratory of Molecular Pathology of Diabetes, DIBIT, H. S. Raffaele, Milan,

and Clinical Staff Coordinator, Diabetes and Endocrine Clinic; H. S. Raffaele, Rome, Italy.

2000-2009: Chief, Laboratory of Molecular Endocrinology and Metabolism, Biomedical

Park Foundation S Raffaele, Rome, Italy

2000-present: Senior Investigator, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

 

Academic positions

2005-present:  Associate Professor of Clinical Biochemistry and Molecular Biology, Department of Experimental Medicine and Surgery, University Tor Vergata, Rome, Italy

Aug/2009-Jan/2010: Visiting Associate Professor at Division of Endocrinology, Diabetes

and Endocrinology Research Center (DERC), Columbia University, Naomi Berrie Diabetes Center

New York, NY

 

Teaching

Prof. F. Barbetti teaches Clinical Biochemisty and Clinical Molecular Biology classes at University of Tor Vergata for students of Medicine and Surgery (course in Italian), for students of Medicine and Surgery (course in English) and for students of Medical Biotechnologies (course in Italian)

 

Research

 

Prof. F. Barbetti focuses his scientific interests on molecular genetics, genotype-phenotype correlations, mechanisms of disease and gene discovery of monogenic forms of diabetes mellitus, of hyperinsulinism and hypoglycemia, and of severe insulin resistance

 

Cenni biografici. Nato a Roma il 29/6/1952.

 

Formazione

1977: Laurea in Medicina e Chirurgia, Univ. La Sapienza, Roma

1981: Specializzazione in Endocrinologia, Univ. La Sapienza, Roma

1988: Dottorato di Ricerca in Scienze Endocrinologiche e Metaboliche, Univ. La Sapienza, Roma 1987-1990: Fogarty fellow, Diabetes Branch, NIDDK, NIH, Bethesda, MD, USA;

1990-1991: Visiting Associate, Diabetes Branch, NIDDK, NIH, Bethesda, MD, USA

 

Posizioni accademiche

2005-presente: Prof. Associato Biochimica Clinica e Biologia Molecolare Clinica, Università Tor Vergata, Roma.

Agosto 2009-Gennaio 2010: Visiting Associate Professor, Dipartimento di Medicina, Sezione Endocrinologia, Diabetes and Endocrinology Research Center (DERC), Columbia University, Naomi Berrie Diabetes Center, New York, NY, USA

 

Attività didattica

La attività didattica del Prof. Barbetti si esplica presso l’Università Tor Vergata nei corsi di laurea di Medicina e Chirurgia in italiano, di Medicina e Chirurgia in inglese e di Biotecnologie Mediche

 

Attività scientifica

Gli interessi scientifici del Prof. Barbetti si concentrano sullo studio genotipo-fenotipo, dei meccanismi di malattia e delle scoperta di nuovi geni alla base delle forme monogeniche di diabete mellito, di iperinsulinismo/ipoglicemia e di insulino-resistenza estrema.

 

Pubblicazioni selezionate

Russo L, Iafusco D, Brescianini S, Nocerino V, Bizzarri C, Toni S, Cerutti F, Monciotti C, Pesavento R, Iughetti L, Bernardini L, Bonfanti R, Gargantini L, Vanelli M, Aguilar-Bryan L, Stazi A, Grasso V, Colombo C, Barbetti F. (2011) Permanent diabetes during the first year of life: multiple gene screening in 54 patients. Diabetologia 54:1693-1701

 

Iafusco D, Bizzarri C, Cadario F, Pesavento R, Tonini G, Tumini S, Cauvin V, Colombo C, Bonfanti R, Barbetti F. (2011) No beta cell desensitisation after a median of 68 months on glibenclamide therapy in patients with KCNJ11-associated permanent neonatal diabetes. Diabetologia 54:2736-2738

 

Iafusco D, Massa O, Pasquino B, Colombo C, Iughetti L, Bizzarri C, Mammì C, Lo Presti D, Suprani T, Schiaffini R, Nichols CG, Russo L, Grasso V, Meschi F, Bonfanti R, Brescianini S, Barbetti F (2012). Minimal Incidence of Neonatal/Infancy Onset Diabetes in Italy is 1:90,000 live births. Acta Diabetol 49:405-408

 

Maiorana A, Barbetti F, Boiani A, Rufini V, Pizzoferro M, Francalanci P, Faletra F, Colin G Nichols, Grimaldi C, de Ville de Goyet J, Rahier J, Henquin J-C, Dionisi-Vici C. (2014) Focal congenital hyperinsulinism managed by medical treatment: a diagnostic algorithm based on molecular genetic screening. Clin Endocrinol, 81:679-688

 

Iafusco D, Salardi S, Chiari G, Toni S, Rabbone I, Pesavento R, Pasquino B, de Benedictis A, Maltoni G, Colombo C, Russo L, Massa O, Sudano M, Cadario F, Porta M, Barbetti F. (2014) No sign of proliferatve retinopathy in 15 patients with Permanent Neonatal Diabetes Mellitus with a median diabetes duration of 24 years. Diabetes Care 37:e181-e182

 

Delvecchio M, Ludovico O, Menzaghi C, Di Paola R, Zelante L, Marucci A, Grasso V, Trischitta V, Carella M, Barbetti F. (2014) Low prevalence of HNF1A mutations after molecular screening of multiple MODY genes in 58 Italian families recruited in the pediatric or adult diabetes clinic from a single Italian hospital. Diabetes Care 37:e258-e260

 

Liu M, Sun J, Cui J, Chen W, Guo H, Barbetti F, Arvan P. (2015) INS-gene mutations: from genetics and beta cell biology and clinical disease. Mol Aspects Med, published online  24 Dicembre 2014