Attuale ruolo
Prof Associato Biologia Molecolare
SSD Bio/11
edificio FNord
piano primo
studio 173
telefono 06-7259.6487
mail candi@uniroma2.it
Eleonora Candi, is Associate Professor in Molecular Biology at the Department of Experimental Medicine and Surgery of the University of Rome “Tor Vergata”. In this University, she received the Doctoral degree in Biology in 1991 and the Ph.D. degree in “Biology and Physiopathology of Epithelia” in 1995. She is currently teaching Molecular Biology to students enrolled to Pharmacy and Biotechnology programs; she is the Coordinator of the Master program in “Nutrition & Cosmetics”. She did her pre- and post-doctoral training, from 1993-1998, at the Skin Biology Branch, NIAMS, National Institute of Health, Bethesda, MD, USA, working under the supervision of Dr PM Steinert on transglutaminases and their substrates. From 1999 to 2001 she received a Telethon Research Fellowship to study the role of transglutaminases in the genetic disease lamellar ichthyosis. Her current scientific interest is programmed cell death in neuro-ectodermal models, in particular she is studying the role of p63, homolog of p53, in epithelia development and tumour formation. She has published 104 peer-reviewed papers for the equivalent 519 in Impact Factor (H-index=39), including: 8 PNAS-USA, 1 Nature Rev Mol Cell Biol, 2 EMBO J, 1 Mol Cell Biol, 6 J Biol Chem, 4 Cell Death Differ and contributed to more than 5 book chapters. She is member of the editorial advisory board of: (i) “Genetic and Molecular Biology” section of the Encyclopaedia Life Science, Wiley-Blackwell; (ii) FEBS Journal, Wiley-Blackwell; (iii) Molecular Cellular Oncology, Landes Biosciences.
Eleonora Candi è Professore Associato in Biologia Molecolare presso il Dipartimento di Medicina Sperimentale e Chirurgia dell’ Università di Roma “Tor Vergata”. Presso questa Università, ha ricevuto nel 1991 la laurea in Biologia e nel 1995 il dottorato di ricerca in “Biologia e Fisiopatologia degli Epiteli”. Insegna Biologia Molecolare nel corso di laurea in Farmacia e nel corso di laurea in Biotecnologie Mediche, inoltre è coordinatore del Master di I livello in “Nutrizione e Cosmesi”. Ha trascorso vari periodi di ricerca e studio all’estero tra cui un periodo di formazione pre- e post- dottorato, dal 1993 al 1998, presso il laboratorio di “Skin Biology”, NIAMS, National Institute of Health, Bethesda, MD, USA, lavorando nel gruppo del Dr Peter Steinert sulle Transglutaminasi e i loro substrati. Dal 1999 al 2001, ha ricevuto una “Telethon Fellowship” (rientro dei cervelli) per studiare il ruolo delle transglutaminasi nella malattia genetica ittiosi lamellare. L’interesse scientifico attuale riguarda la morte cellulare programmata nei modelli neuro-ectodermici, in particolare lo studio del ruolo di p63, omologo a p53, nello sviluppo degli epiteli e nella formazione dei tumori. Ha pubblicato 104 articoli su riviste internazionali, per un “Impact Factor” totale di 519 (H-index=39), tra cui: 8 PNAS-USA, 1 Nature Rev Mol Cell Biol, 2 EMBO J, 1 Mol Cell Biol, 6 J Biol Chem, 4 Cell Death Differ ed ha contribuito alla stesura di più di 5 capitoli di libri. E’ membro del “editorial advisory board” di: (i) sezione di “Genetica e Biologia Molecolare” di “Encyclopaedia Life Science”, Wiley-Blackwell; ((ii) FEBS Journal, Wiley-Blackwell; iii) Molecular Cellular Oncology, Landes Biosciences.
Pubblicazioni ultimi 5 anni/oppure quelle più rilevanti
10 pubblicazioni più rilevanti:
1. Amelio I, et al. miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration. J Cell Biology. 2012;199(2):347-63. [IF: 10.264]
2. Rivetti di Val Cervo P, et al. p63-microRNA feedback in keratinocyte senescence. Proc Natl Acad Sci U S A. 2012. 109(4):1133-8. [IF: 9.771]
3. Agostini M, et al. microRNA-34a regulates neurite outgrowth, spinal morphology, and function. Proc Natl Acad Sci U S A. 2011. 108(52):21099-104. [IF: 9.771]
4. Agostini M, et al. Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets. Proc Natl Acad Sci U S A. 2011. 108(52):21093-8. [IF: 9.771]
5. Notari M, et al. Inhibitor of apoptosis-stimulating protein of p53 (iASPP) prevents senescence and is required for epithelial stratification. Proc Natl Acad Sci U S A. 2011. 108(40):16645-50. [IF: 9.771]
6. Boase NA, et al. Respiratory distress and perinatal lethality in Nedd4-2-deficient mice. Nature Commun. 2011;2:287. [IF: 12.764]
7. Busuttil V, et al. NF-kappaB inhibits T-cell activation-induced, p73-dependent cell death by induction of MDM2. Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18061-6. [IF: 9.771]
8. Gonfloni S, et al. Inhibition of the c-Abl-TAp63 pathway protects mouse oocytes from chemotherapy-induced death. Nature Medicine. 2009.15(10):1179-85. [IF: 27.553]
9. Candi E, et al. DeltaNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2. Proc Natl Acad Sci U S A. 2007.104(29):11999-2004. [IF=9.643]
10. Sayan BS, et al. Cleavage of the transactivation-inhibitory domain of p63 by caspases enhances apoptosis. Proc Natl Acad Sci U S A. 2007. 104(26):10871-6 [IF=9.643]
REVIEWS
1. Dötsch V, et al. p63 and p73, the ancestors of p53. Cold Spring Harb Perspect Biol. 2010 Sep;2(9):a004887.
2. Aberdam D, el al. miRNAs, ‘stemness’ and skin. Trends Biochem Sci. 2008. 33(12):583-91
3. Candi E, et al. The cornified envelope: a model of cell death Nature Reviews Molec. Cell. Biol. 2005. 6:328-40