Attuale ruolo: Professore Ordinario
SSD: MED/12
Edificio: Torre E1 sud
Piano: 5°
Studio: stanza 501
Telefono: 06 72596801
Mail: angelico@med.uniroma2.it
Sito Web: epatologia@ptvonline.it
- Born in Rome, in Dec.1949
- M.D. degree at University La Sapienza Medical School, Rome, in 1974
- Specialist Degree in Gastroenterology in 1978
- Specialist Degree in Clinical Pathology in 1984
Academic appointments
- Full time researcher at the Gastroenterology Unit of La Sapienza University in Rome, from 1980 until 1991
- Research Fellow in Gastroenterology at the Digestive Disease Center, Harvard Medical School, Boston, in 1984-85
- Associate Professor of Gastroenterology at the University of Catania, Medical School from (1992-1995)
- Associate Professor of Gastroenterology at the University of Rome “Tor Vergata”, Medical School (1995-1999)
- Full Professor of Gastroenterology at the University of Rome “Tor Vergata”, Medical School from 2000 until present
Clinical appointments
- Assistant Professor of Gastroenterology at the academic Hospital of La Sapienza University (1980-1991), Catania University (1992-1995), Tor Vergata University (1995-1999).
- Director, Gastroenterology and Hepatology Unit, Fatebenefratelli Hospital, Rome (2001- 2004).
- Director of Hepatology, Liver Transplantation Program of the University of Rome Tor Vergata, (from 1992 until present).
- Director of Hepatology Unit, Tor Vergata University Hospital, Viale Oxford, 81/00133, Rome – Italy (from 2000 until present).
Main areas of scientific interest and research
- Author of 211 publications (indexed in Pub.Med) in peer-reviewed international journals, mainly involving the following fields:
o Cholestatic disorders
o Chronic liver disease
o Liver Transplantation
o Bile secretion and bile acids
o Gallstone disease
o Portal Hypertension
o Viral hepatitis
o Liver Cancer
Editorial activities
· Editor-in-Chief of Digestive and Liver Disease (Elsevier).
· Member of the editorial board of the following journals: Hepatology; Gastroenterologie Clinique et Biologique; World Journal of Gastroenterology Giornale di Gastroenterologia; Minerva Gastroenterologica e Dietologica; Current opinion in Hepatology.
Membership of scientific societies
- Italian Society of Gastroenterology (SIGE)
- Italian Association for the Study of the Liver (AISF)
- American Gastroenterological Association (AGA)
- American Society of the Study of the Liver (AASLD)
- European Association for the Study of the Liver (EASL)
Coordination of Scientific Commission and Study Groups
· Coordinator of the Commission on Cholestasis (2000-2002) of the Italian Association for the Study of the Liver (AISF)
· Coordinator of the Commission on Liver Transplantation (2002-2004 and 2006-2008) of the Italian Association for the Study of the Liver (AISF)
· Principal Investigator and coordinator of the Liver Match Study (an Italian nationwide observational study on Liver Transplantation)
· Nato a Roma nel 1949
· Laurea in Medicina nel 1974 presso l’Università di Roma La Sapienza
· Specializzazione in Gastroenterologia nel 1978
· Specializzazione in Patologia Clinica nel 1984
Esperienze Accademiche
· Ricercatore a tempo pieno presso la Cattedra di Gastroenterologia II dell’Università La Sapienza, Roma, dal 1980 al 1991, con particolari interessi in studi sulla fisiopatologia della secrezione biliare e nella gestione clinica di malati con patologie del fegato e della vie biliari.
· Research Fellow in Gastroenterologia presso l’Harvard Digestive Disease Center, Harvard Medical School, Boston, nel 1984-85.
· Professore Associato di Gastroenterologia presso la Facoltà di Medicina dell’Università di Catania dal 1992 al 1995.
· Professore Associato di Gastroenterologia presso l’Università di Roma “Tor Vergata”, Facoltà di Medicina e Chirurgia, dal 1995 al 1999.
· Professore Ordinario di Gastroenterologia presso l’Università di Roma “Tor Vergata”, Facoltà di Medicina e Chirurgia, dal 2000 a oggi.
Esperienze cliniche
· Assistente di Gastroenterologia presso il Policlinico Universitario Umberto I di Roma (1980/1991), l’Univesrsità di Catania (1992/1995), l’Università di Tor Vergata (1995/1999).
· Direttore dell’Unità di Gastroenterologia ed Epatologia presso l’Ospedale Fatebenefratelli di Roma (2001/2004).
· Direttore del Programma di Epatologia e Trapianto di fegato presso l’Università di Roma Tor Vergata (dal 1992 ad oggi).
· Direttore dell’Unità di Epatologia presso il Policlinico Universitario Tor Vergata di Roma (dal 2000 ad oggi).
Principali aree di interesse scientifico e di ricerca
· Autore di oltre 350 pubblicazioni, tra le quali 211 “full papers” pubblicati in riviste internazionali “peer-reviewed”, prevalentemente concernenti le seguenti aree di ricerca:
o Sindromi colestatiche
o Epatopatie croniche virali e non virali
o Trapianto di fegato
o Secrezione e acidi biliari
o Litiasi biliare e sue complicanze
o Ipertensione Portale
o Epatiti virali
o Epatocarcinoma
Attività editoriali
· Editor in Chief della rivista internazionale Digestive and Liver Disease (Elsevier), dal gennaio 2009 IF 2.805
· Membro dell’editorial board delle seguenti riviste scientifiche: Hepatology; Gastroenterologie Clinique et Biologique; World Journal of Gastroenterology; Giornale di Gastroenterologia; Minerva Gastroenterologica e Dietologica; Current opinion in Hepatology.
Membro delle seguenti società scientifiche:
· Società Italiana di Gastroenterologia (SIGE)
· Associazione Italiana per lo Studio sul Fegato (AISF)
· American Gastroenterological Association (AGA)
· American Society of the Study of the Liver (AASLD)
· European Association for the Study of the Liver (EASL)
Coordinamento di Commissioni Scientifiche e Gruppi di Studio:
· Coordinatore della Commissione sulla Colestasi dell’Associazione Italiana per lo Studio sul Fegato (AISF).
· Coordinatore della Commissione del Trapianto di Fegato (2002-2004 e 2006-2008) dell’Associazione Italiana per lo Studio sul Fegato (AISF).
· Principale Investigator e coordinatore dello studio Liver Match (studio osservazionale italiano multicentrico sul trapianto di fegato).
Pubblicazioni ultimi 5 anni
Pellicelli AM, Montalbano M, Lionetti R, Durand C, Ferenci P, D’Offizi G, Knop V, Telese A, Lenci I, Andreoli A, Zeuzem S, Angelico M. Sofosbuvir plus daclatasvir for post-transplant recurrent hepatitis C: Potent antiviral activity but no clinical benefit if treatment is given late. Dig Liver Dis. 2014 Oct;46(10):923-7. doi: 10.1016/j.dld.2014.06.004.
Andriulli A, Nardi A, Di Marco V, Ippolito AM, Gavrila C, Aghemo A, Di Paolo D, Squadrito G, Grassi E, Calvaruso V, Valvano MR, Brancaccio G, Craxi A, Angelico M. An a priori prediction model of response to peginterferon plus ribavirin dual therapy in naïve patients with genotype 1 chronic hepatitis C. Dig Liver Dis. 2014 Sep;46(9):818-25. doi: 10.1016/j.dld.2014.05.015.
Buscarini E, Conte D, Cannizzaro R, Bazzoli F, De Boni M, Delle Fave G, Farinati F, Ravelli P, Testoni PA, Lisiero M, Spolaore P; Italian Association of Hospital Gastroenterologists and Endoscopists (AIGO), Italian Society of Endoscopy (SIED), Italian Society of Gastroenterology (SIGE). White paper of Italian Gastroenterology: delivery of services for digestive diseases in Italy: weaknesses and strengths. Dig Liver Dis. 2014 Jul;46(7):579-89. doi: 10.1016/j.dld.2014.02.019.
Ponziani FR, Viganò R, Iemmolo RM, Donato MF, Rendina M, Toniutto P, Pasulo L, Morelli MC, Burra P, Miglioresi L, Merli M, Di Paolo D, Fagiuoli S, Gasbarrini A, Pompili M; AISF RECOLT-C Group, Belli L, Gerunda GE, Marino M, Montalti R, Di Benedetto F, De Ruvo N, Rigamonti C, Colombo M, Rossi G, Di Leo A, Lupo L, Memeo V, Bringiotti R, Zappimbulso M, Bitetto D, Vero V, Colpani M, Fornasiere E, Pinna AD, Morelli MC, Bertuzzo V, De Martin E, Senzolo M, Ettorre GM, Visco-Comandini U, Antonucci G, Angelico M, Tisone G, Giannelli V, Giusto M. Long-term maintenance of sustained virological response in liver transplant recipients treated for recurrent hepatitis C. Dig Liver Dis. 2014 May;46(5):440-5. doi: 10.1016/j.dld.2014.01.157.
Angelico M, Nardi A, Romagnoli R, Marianelli T, Corradini SG, Tandoi F, Gavrila C, Salizzoni M, Pinna AD, Cillo U, Gridelli B, De Carlis LG, Colledan M, Gerunda GE, Costa AN, Strazzabosco M; Liver Match Study Investigators; Liver Match Steering Committee:; AISF/CPT Governing Board; CNT Governing Board; Participating Transplant Centres & Investigators; Data Collection and Verification and Biostatistics. A Bayesian methodology to improve prediction of early graft loss after liver transplantation derived from the Liver Match study.
Dig Liver Dis. 2014 Jan 9. pii: S1590-8658(13)00658-0. doi: 10.1016/j.dld.2013.11.004.
Orlacchio A, Bolacchi F, Chegai F, Bergamini A, Costanzo E, Del Giudice C,Angelico M, Simonetti G. Comparative evaluation of percutaneous laser and radiofrequency ablation in patients with HCC smaller than 4 cm. Radiol Med. 2013 Nov 26.
Francioso S, Almerighi C, Forte P, Bandiera F, Nosotti L, Lionetti R, Taliani G, Piras MR, Ponti ML, Parruti G, Di Candilo F, Gentile S, Piccolo P, Salso A,Riccobelli F, Renzi S, Longo MA, Montalbano M, Zaru S, Biliotti E, Di Masi F, Santopaolo F, Angelico M. A simple rule to personalize standard dual therapy across all genotypes in naive chronic hepatitis C patients: The TT4 randomized trial. Dig Liver Dis. 2013 Nov 12. doi:pii: S1590-8658(13)00610-5.
Manzia TM, Angelico R, Baiocchi L, Toti L, Ciano P, Palmieri G, Angelico M, Orlando G, Tisone G. The Tor Vergata weaning of immunosuppression protocols in stable hepatitis C virus liver transplant patients: the 10-year follow-up. Transpl Int. 2013 Mar;26(3):259-66. doi: 10.1111/tri.12023.
Andriulli A, Marco VD, Margaglione M, Ippolito AM, Fattovich G, Smedile A,Valvano MR, Calvaruso V, Gioffreda D, Milella M, Morisco F, Felder M, Brancaccio G, Fasano M, Gatti P, Tundo P, Barone M, Cozzolongo R, Angelico M, D’Andrea G,Andriulli N, Abate ML, Mazzella G, Gaeta GB, Craxi A, Santantonio T. Identification of Naïve Hcv-1 Patients with Chronic Hepatitis who may Benefit from Dual Therapy with Peg-Interferon and Ribavirin. J Hepatol. 2014 Jan;60(1):16-21. doi: 10.1016/j.jhep.2013.07.040. Epub 2013 Aug 20.
Burra P, Belli L, Fagiuoli S, Angelico M, Costa AN, Caraceni P, Toniutto P.Skills and Requirements of a Transplant Hepatologist: Board Certification of the Italian Association for the Study of the Liver (AISF). Dig Liver Dis. 2013 Dec;45(12):992-4. doi: 10.1016/j.dld.2013.04.014. Epub 2013 Jun 28.
Cento V, Van Hemert F, Neumann-Fraune M, Mirabelli C, Di Maio VC, Salpini R, Bertoli A, Micheli V, Gubertini G, Romano S, Visca M, De Sanctis GM, Berkhout B, Marino N, Mazzotta F, Cappiello G, Spanò A, Sarrecchia C, Ceccherini-Silberstein F, Andreoni M, Angelico M, Verheyen J, Perno CF, Svicher V. Anti-HBV treatment induces novel reverse transcriptase mutations with reflective effect on HBV S antigen. J Infect. 2013 Oct;67(4):303-12. doi: 10.1016/j.jinf.2013.05.008. Epub 2013 Jun 22.
Cesaro P, Kohn A, Petruziello L, Angelico M, Franceschi F, Gigliozzi A, Lamazza A, Tammaro L, Boschetto S, Brighi S, Antoniozzi A, Baiocchi L. A survey on mortality from non-variceal upper gastrointestinal bleeding: Is the emergency referral system adequate? Dig Liver Dis. 2013 Nov;45(11):953-6. doi: 10.1016/j.dld.2013.04.010. Epub 2013 Jun 5.
Salpini R, Alteri C, Cento V, Pollicita M, Micheli V, Gubertini G, De Sanctis GM, Visca M, Romano S, Sarrecchia C, Andreoni M, Angelico M, Parruti G, Svicher V, Perno CF. Snapshot on drug-resistance rate and profiles in patients with chronic hepatitis B receiving nucleos(t)ide analogues in clinical practice. J Med Virol. 2013 Jun;85(6):996-1004. doi: 10.1002/jmv.23567.
Angelico M, Nardi A, Marianelli T, Caccamo L, Romagnoli R, Tisone G, Pinna AD,Avolio AW, Fagiuoli S, Burra P, Strazzabosco M, Costa AN; Liver Match Investigators. Hepatitis B-core antibody positive donors in liver transplantation and their impact on graft survival: evidence from the Liver Match cohort study. J Hepatol. 2013 Apr;58(4):715-23. doi: 10.1016/j.jhep.2012.11.025. Epub 2012 Nov
Sulkowski MS, Poordad F, Manns MP, Bronowicki JP, Rajender Reddy K, Harrison SA, Afdhal NH, Sings HL, Pedicone LD, Koury KJ, Sniukiene V, Burroughs MH, Albrecht JK, Brass CA, Jacobson IM; SPRINT-2 Trial Investigators. Anemia during treatment with peginterferon Alfa-2b/ribavirin and boceprevir: Analysis from the serine protease inhibitor therapy 2 (SPRINT-2) trial. Hepatology. 2013 Mar;57(3):974-84. doi: 10.1002/hep.26096. Epub 2013 Feb 11
Piccolo P, Lenci I, di Paolo D, Demelia L, Sorbello O, Nosotti L, Angelico M. A randomized controlled trial of sequential pegylated interferon-α and telbivudine or vice versa for 48 weeks in hepatitis B e antigen-negative chronic hepatitis B. Antivir Ther. 2013;18:57-64.
Angelico M, Nardi A, Marianelli T, Caccamo L, Romagnoli R, Tisone G, Pinna AD, Avolio AW, Fagiuoli S, Burra P, Strazzabosco M, Costa AN; For the Liver Match Investigators. Hepatitis B-core antibody positive donors in liver transplantation and their impact on graft survival: Evidence from the Liver Match cohort study. J Hepatol. 2012;28.
Manzia TM, Angelico R, Toti L, Lai Q, Ciano P, Angelico M, Tisone G. Hepatitis C virus recurrence and immunosuppression-free state after liver transplantation. Expert Rev Clin Immunol. 2012;8:635-44.
Angelico M. Unexplained hepatic deterioration–keep in mind hepatitis E virus infection! Dig Liver Dis. 2012;44:895-6.
Carbone M, Campagnolo L, Angelico M, Tisone G, Almerighi C, Telesca C, Lenci I, Moscatelli I, Massoud R, Baiocchi L. Leptin attenuates ischemia-reperfusion injury in the rat liver. Transpl Int. 2012;25:1282-8.
Cento V, Mirabelli C, Salpini R, Dimonte S, Artese A, Costa G, Mercurio F, Svicher V, Parrotta L, Bertoli A, Ciotti M, Di Paolo D, Sarrecchia C, Andreoni M, Alcaro S, Angelico M, Perno CF, Ceccherini-Silberstein F. HCV genotypes are differently prone to the development of resistance to linear and macrocyclic protease inhibitors. PLoS One. 2012;7:e39652.
Poordad F, Bronowicki JP, Gordon SC, Zeuzem S, Jacobson IM, Sulkowski MS, Poynard T, Morgan TR, Molony C, Pedicone LD, Sings HL, Burroughs MH, Sniukiene V, Boparai N, Goteti VS, Brass CA, Albrecht JK, Bacon BR; SPRINT-2 and RESPOND-2 Investigators. Factors that predict response of patients with hepatitis C virus infection to boceprevir. Gastroenterology. 2012;143:608-18.e1-5.
Giannelli V, Giusto M, Farcomeni A, Ponziani FR, Pompili M, Viganò R, Iemmolo RM, Donato MF, Rendina M, Toniutto P, Pasulo L, Morelli MC, De Martin E, Miglioresi L, Di Paolo D, Fagiuoli S, Merli M; AISF RECOLT-C group study. Treatment of hepatitis C recurrence is less successful in female than in male liver transplant recipients. Transpl Int. 2012;25:448-54.
Orlacchio A, Bolacchi F, Antonicoli M, Coco I, Costanzo E, Tosti D, Francioso S, Angelico M, Simonetti G. Liver elasticity in NASH patients evaluated with real-time elastography (RTE). Ultrasound Med Biol. 2012;38:537-44.
Svicher V, Cento V, Bernassola M, Neumann-Fraune M, Van Hemert F, Chen M, Salpini R, Liu C, Longo R, Visca M, Romano S, Micheli V, Bertoli A, Gori C, Ceccherini-Silberstein F, Sarrecchia C, Andreoni M, Angelico M, Ursitti A, Spanò A, Zhang JM, Verheyen J, Cappiello G, Perno CF. Novel HBsAg markers tightly correlate with occult HBV infection and strongly affect HBsAg detection. Antiviral Res. 2012;93:86-93.
Almerighi C, Bergamini A, Lionetti R, Sinistro A, Lenci I, Tariciotti L, Tisone G, Angelico M. Vitamin D3 modulates T lymphocyte responses in hepatitis C virus-infected liver transplant recipients. Dig Liver Dis. 2012;44:67-73.
Svicher V, Cento V, Bernassola M, Neumann-Fraune M, Hemert FV, Chen M, Salpini R, Liu C, Longo R, Visca M, Romano S, Micheli V, Bertoli A, Gori C, Ceccherini-Silberstein F, Sarrecchia C, Andreoni M, Angelico M, Ursitti A, Spanò A, Zhang JM, Verheyen J, Cappiello G, Perno CF. Novel HBsAg markers tightly correlate with occult HBV infection and strongly affect HBsAg detection. Antiviral Res. 2011 Nov 9.
Salpini R, Svicher V, Cento V, Gori C, Bertoli A, Scopelliti F, Micheli V, Cappiello T, Spanò A, Rizzardini G, De Sanctis GM, Sarrecchia C, Angelico M, Perno CF. Characterization of drug-resistance mutations in HBV D-genotype chronically infected patients, naïve to antiviral drugs. Antiviral Res. 2011 Nov;92(2):382-5.
Angelico M. Epidemiology and outcome of hepatitis C relapse in transplant recipients. Transplant Proc. 2011 Jul-Aug;43(6):2457-8.
Svicher V, Cento V, Salpini R, Mercurio F, Fraune M, Beggel B, Han Y, Gori C, Wittkop L, Bertoli A, Micheli V, Gubertini G, Longo R, Romano S, Visca M, Gallinaro V, Marino N, Mazzotta F, De Sanctis GM, Fleury H, Trimoulet P, Angelico M, Cappiello G, Zhang XX, Verheyen J, Ceccherini-Silberstein F, Perno CF. Role of hepatitis B virus genetic barrier in drug-resistance and immune-escape development. Dig Liver Dis. 2011 Dec;43(12):975-83.
Manzia TM, Angelico R, Toti L, Cillis A, Ciano P, Orlando G, Anselmo A, Angelico M, Tisone G. Glycogen storage disease type Ia and VI associated with hepatocellular carcinoma: two case reports.Transplant Proc. 2011 May;43(4):1181-3.
Manzia TM, Gravante G, Di Paolo D, Orlando G, Toti L, Bellini MI, Ciano P, Angelico M, Tisone G. Liver transplantation for the treatment of nodular regenerative hyperplasia. Dig Liver Dis. 2011 Dec;43(12):929-34.
Poordad F, McCone J Jr, Bacon BR, Bruno S, Manns MP, Sulkowski MS, Jacobson IM, Reddy KR, Goodman ZD, Boparai N, DiNubile MJ, Sniukiene V, Brass CA, Albrecht JK, Bronowicki JP; SPRINT-2 Investigators. Boceprevir for untreated chronic HCV genotype 1 infection. N Engl J Med. 2011;364(13):1195-206.
Manzia TM, Angelico R, Toti L, Bellini MI, Sforza D, Palmieri G, Orlando G, Tariciotti L, Angelico M, Tisone G. Long-term, maintenance MMF monotherapy improves the fibrosis progression in liver transplant recipients with recurrent hepatitis C. Transpl Int. 2011;24(5):461-8.
Lenci I, Tisone G, Di Paolo D, Marcuccilli F, Tariciotti L, Ciotti M, Svicher V, Perno CF, Angelico M. Safety of complete and sustained prophylaxis withdrawal in patients liver-transplanted for HBV-related cirrhosis at low risk of HBV recurrence. J Hepatol. 2011;55(3):587-93.
Angelico M, Cillo U, Fagiuoli S, Gasbarrini A, Gavrila C, Marianelli T, Costa AN, Nardi A, Strazzabosco M, Burra P, Agnes S, Baccarani U, Calise F, Colledan M, Cuomo O, De Carlis L, Donataccio M, Ettorre GM, Gerunda GE, Gridelli B, Lupo L, Mazzaferro V, Pinna A, Risaliti A, Salizzoni M, Tisone G, Valente U, Rossi G, Rossi M, Zamboni F; Liver Match Investigators. Liver Match, a prospective observational cohort study on liver transplantation in Italy: study design and current practice of donor-recipient matching.Dig Liver Dis. 2011 Feb;43(2):155-64.
Orlacchio A, Bolacchi F, Petrella MC, Pastorelli D, Bazzocchi G, Angelico M, Simonetti G. Liver contrast enhanced ultrasound perfusion imaging in the evaluation of chronic hepatitis C fibrosis: preliminary results. Ultrasound Med Biol. 2011 Jan;37(1):1-6.
Svicher V, Alteri C, Gori C, Salpini R, Marcuccilli F, Bertoli A, Longo R, Bernassola M, Gallinaro V, Romano S, Visca M, Ursitti A, Feasi M, Micheli V, Angelico M, Cassola G, Parruti G, Gubertini G, De Sanctis GM, Ceccherini-Silberstein F, Cappiello G, Spanò A, Perno CF. Lamivudine-resistance mutations can be selected even at very low levels of hepatitis B viraemia. Dig Liver Dis. 2010 Dec;42(12):902-7.