Attuale ruolo Ricercatore Confermato
SSD BIO 10
edificio F Nord
piano Primo
studio F164
telefono +390672596464
mail Divenere@med.uniroma2.it
Education M.S. University Degree in Physics,Rome Tor Vergata PhD in Biology and Physiopathology of Epithelium Advanced Courses -“III national School on Synchrotron radiation”, Italy, 1995. -“Summer School – Applications of Synchrotron Radiation in Life Sciences and Chemistry”Italy, 1996. -“Sixth International Summer School on Biophysics – Supramolecular Structure and Function”. Rovinj, Croazia, 1997. -“Protein Structure”. Italy, 1998. -School of the Italian Pure and Applied Biophysics Society “Spectroscopies and Computational Methods in the Study of Biological Systems”; Italy, 1999. From 2002 Full Research in Biochemistry, “Tor Vergata” University, Rome. Scientific activity Protein structure to function relationship: a. conformational stability studies of proteins by equilibrium unfolding measurements; b. kinetic measurements of the folding/unfolding process of metal containing proteins; c. structural and functional behavior of monomeric and oligomeric enzymes under high pressure condition. Spectroscopic techniques: A. Di Venere has a very good knowledge of fluorescence dynamics (both in phase and time-resolved techniques), circular dichroism and rotational dynamics measurements of proteins in solution. She is author of about 40 scientific publications (IF 95) in the fields of optical spectroscopy of biological molecules, fluorescence instrumentation and biomaterials..Titoli di studio Ha conseguito la Laurea in Fisica presso l’Universita’ degli Studi di Roma Tor Vergata nel 1994. Consegue il titolo di dottore di ricerca in Biologia e Fisiopatologia degli Epiteli presso l’Università degli Studi di Roma “Tor Vergata nel 2000 Corsi di Aggiornamento -“III Scuola Nazionale di Luce di Sincrotrone” S.ta Margherita di Pula, Italia, 2-11 Ottobre 1995. -“Summer School – Applications of Synchrotron Radiation in Life Sciences and Chemistry” Maratea, Italia, 2-10 Ottobre 1996. -“Sixth International Summer School on Biophysics – Supramolecular Structure and Function”. Rovinj, Croazia, 15-27 Settembre 1997. -“Struttura delle proteine”. L’Aquila, Italia, 6-8 Maggio 1998. – Scuola di Biofisica Pura ed Applicata “Spettroscopie e metodi computazionali nello studio dei sistemi biologici” Venezia, Italia, 25-29 Gennaio 1999. Campi di Interesse Scientifico Analisi della struttura e della funzione di proteine e membrane biologiche mediante tecniche spettroscopiche ed in particolare su: a) Studi cinetici di folding/unfolding b) Struttura di proteine ad alte pressioni c) Studi della dinamica conformazionale delle proteine tramite misure di denaturazione d) Studi dell’interazione proteina-membrana E’ autrice di circa 40 pubblicazioni scientifiche (IF 95) su riviste internazionali.
Pubblicazioni ultimi 5 anni/oppure quelle più rilevanti
Characterization of monomeric substates of ascorbate oxidase.
A. Di Venere, E. Nicolai, N. Rosato, A. Rossi, A. Finazzi Agro’ and G. Mei
The Febs Journal, 278, 1585-1593 (2011). IF=3.04
Tight association of N-terminal and catalytic subunits of rabbit 12/15-lipoxygenase is important for protein stability and catalytic activity
A. Di Venere, I. Ivanov, T. Horn, P. Scheerer, E. Nicolai, S. Stehling, C. Richter, E. Skrzypczak-Jankun, G. Mei, M. Maccarrone and H. Kühn
Biochim Biophys Acta – Molecular and Cell Biology of Lipids 1811, 1001-1010 (2011). IF=5.08
Ligand Induced Formation of Transient Dimers of Mammalian 12/15-Lipoxygenase: a Key to Allosteric Behavior of this Class of Enzymes?
I. Ivanov, W. Shang, L. Toledo, L. Masgrau, D. I. Svergun, S. Stehling, H. Gómez, A. Di Venere, G. Mei, J. M. Lluch, E. Skrzypczak-Jankun, À. González-Lafont and H. Kühn
Proteins 80, 703-712 (2012). IF=2.81
The endocannabinoid 2-arachidonoylglicerol decreases calcium induced cytochrome c release from liver mitochondria
P. Zaccagnino, S. D’Oria, L. Luciano Romano, A. Di Venere, A. M. Sardanelli and M. Lorusso
Journal of Bioenergetics and Biomembranes, 44, 273-280 (2012). IF= 3.637
Rat and human fatty acid amide hydrolases: Overt similarities and hidden differences.
Di Venere A, Dainese E, Fezza F, Angelucci BC, Rosato N, Cravatt BF, Finazzi-Agrò A, Mei G, Maccarrone M.
Biochim Biophys Acta – Molecular and Cell Biology of Lipids. 1821(11):1425-1433 (2012). IF=5.27
Role of Arg403 for thermostability and catalytic activity of rabbit 12/15-lipoxygenase.
Di Venere A, Horn T, Stehling S, Mei G, Masgrau L, González-Lafont À, Kühn H, Ivanov I
Biochim Biophys Acta – Molecular and Cell Biology of Lipids. 1831(6):1079-1088 (2013) IF=4.8
Molecular basis for the catalytic inactivity of a naturally occurring near-null variant of human ALOX15
Horn T, Ivanov I, Di Venere A, Kakularam KR, Reddanna P, Conrad ML, Richter C, Scheerer P, Kuhn H.
Biochim Biophys Acta – Molecular and Cell Biology of Lipids. 1831 (12): 1702-1712 (2013) IF=4.8
Di Venere A, Nicolai E, Ivanov I, Dainese E, Adel S, Angelucci BC, Kuhn H, Maccarrone M, Mei G.
Biochim Biophys Acta – Molecular and Cell Biology of Lipids. 1841 (1): 1-10 (2014) IF=4.8 (2014)
Dynamics and flexibility of human aromatase probed by FTIR and time resolved fluorescence spectroscopy.
Di Nardo G, Breitner M, Sadeghi SJ, Castrignanò S, Di Venere A, Nicolai E, Mei G, Allegra P, Gilardi G.
Plos One (2013) DOI: 10.1371/journal.pone.0082118. IF=3.7
Modules identification in protein structures: the topological and geometrical solutions.
Tasdighian S, Di Paola L, De Ruvo M, Paci P, Santoni D, Palumbo P, Mei G, Di Venere A, Giuliani A.
J Chem Inf Model. 54:159-168 (2014) IF=4.3
Highly specific ubiquitin-competing molecules effectively promote frataxin
accumulation and partially rescue the aconitase defect in Friedreich ataxia cells.
Rufini A, Cavallo F, Condò I, Fortuni S, De Martino G, Incani O, Di Venere A, Benini M, Damiano S Massaro D M, Arcuri G, Serio D, Malisan F, Testi R.
Neurobiology of disease. 75: 91-99 (2015) IF=5.5